Stay inside the old town or in Triana. Day-trip Córdoba only if you have a third night. Granada is a separate stay.
The cathedral–Alcázar cluster
Everything that matters on a first visit sits here. Walk. Do not taxi between them.
Santa Cruz
The maze you sleep in if you want orange trees outside the window. Restaurants on the edge are better than those on the monument doorstep.
Triana
Ceramics, flamenco, and the river. A different Seville after dark.
Plaza de España and Parque de María Luisa
A half-day of tiles and shade. Useful when the Alcázar ticket is in the afternoon.